Scholarly Work

Hameed S. S., Sharma T. P. Generation of Retinal Ganglion Cells from Reprogrammed Keratocytes of Non-glaucoma and Glaucoma donors, Curr Protoc. 2025 Jan;5(1):e70091.doi: 10.1002/cpz1.70091. 

Ho K., Bodi, N. E., Sharma T.P. Normal-Tension Glaucoma and Potential Clinical Links to Alzheimer’s Disease. J. Clin. Med. 2024, 13(7), 1948. 

Hameed S.S., Bodi N.E., Miller R.C., Sharma T.P. Neuritin 1 drives therapeutic preservation of retinal ganglion cells in an ex-vivo human glaucoma model. J Ocul Pharmacol Ther. 2024 Jul 12. doi: 10.1089/jop.2024.0041. 

Soucy, J.R., et al. Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium. Mol Neurodegeneration 18, 64, 2023. 

Peng M., Curry, S. M, Liu, Y., Lohawala, H., Sharma G., Sharma T.P. The Ex-Vivo Human Translaminar Autonomous System to Study SANS Pathogenesis. npj Microgravity volume 8, Article number: 44 2022 

Peng M., Margetts T. J., Sugali C.K., Rayana N.P., Dai J., Sharma T.P., Raghunathan V. K., Mao W. An ex vivo model of human corneal rim perfusion organ culture. Exp Eye Res. 2022 Jan;214: 108891. 

Peng M., Park B., Harikrishnan H., Jahan S., Dai J., Rayana N.P., Sugali C.K., Sharma T.P., Imanishi S., Imanishi Y., Corson T. W., Mao W. A smartphone-based method for mouse fundus imaging. Exp Eye Res. 2021 May; 206:108530. 

Sharma, T. P., Curry, S. M., Lohawala, H., McDowell, C. Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments. J. Vis. Exp. (158), e61006, 2020. 

Sharma TP, Curry SM, McDowell CM. Effects of TLR4 inhibition on TGFβ2 signaling in the human trabecular meshwork. J Ocul Pharmacol Ther. 2019 Dec 13. 

Sharma TP, Giacalone JC, Burnight ER, Fingert JF, Mullins RF, Stone EM, Tucker BA. CRISPR-Cas9-Based Genome Editing of Human Induced Pluripotent Stem Cells.  Curr Protoc Stem Cell Biol. 2018 Feb 28;44:5 

Jain A, Zode G, Kasetti RB, Ran FA, Yan W, Sharma TP, Bugge K, Searby CC, Fingert JH, Zhang F, Clark AF, Sheffield VC. CRISPR-Cas9-based treatment of myocilin-associated glaucoma. Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11199-11204. 

Sharma TP, Wiley LA, Whitmore SS, Anfinson KR, Cranston CM, Oppedal DJ, Daggett HT, Mullins RF, Tucker BA, Stone EM. Patient-specific induced pluripotent stem cells to evaluate the pathophysiology of TRNT1-associated Retinitis pigmentosa. Stem Cell Res. 2017 May; 21:58-70. Cover of journal. 

DeLuca AP, Whitmore SS, Barnes J, Sharma TP, Westfall TA, Scott CA, Weed MC, Wiley JS, Wiley LA, Johnston RM, Schnieders MJ, Lentz SR, Tucker BA, Mullins RF, Scheetz TE, Stone EM, Slusarski DC. Hypomorphic mutations in TRNT1 cause retinitis pigmentosa with erythrocytic microcytosis. Hum Mol Genet. 2016 Jan 1;25(1):44-56. 

Sharma TP, Liu Y, Wordinger RJ, Pang IH, Clark AF. Neuritin 1 promotes retinal ganglion cell survival and axonal regeneration following optic nerve crush. Cell Death Dis. 2015 Feb 26;6:e1661. 

Sharma TP, McDowell CM, Liu Y, Wagner AH, Thole D, Faga BP, Wordinger RJ, Braun TA, Clark AF. Optic nerve crush induces spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice. Mol Neurodegener. 2014 Apr 27;9:14. 

Bollinger KE, Crabb JS, Yuan X, Putliwala T, Clark AF, Crabb JW. Proteomic similarities in steroid responsiveness in normal and glaucomatous trabecular meshwork cells. Mol Vis. 2012;18:2001-11. 2012 Jul 20. 

McDowell CM, Luan T, Zhang Z, Putliwala T, Wordinger RJ, Millar JC, John SW, Pang IH, Clark AF. Mutant human myocilin induces strain specific differences in ocular hypertension and optic nerve damage in mice. Exp Eye Res. 2012 Jul;100:65-72. 

Bollinger KE, Crabb JS, Yuan X, Putliwala T, Clark AF, Crabb JW. Quantitative proteomics: TGFβ₂ signaling in trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2011 Oct 21;52(11):8287-94. 

Pritham EJ, Putliwala T, Feschotte C. Mavericks, a novel class of giant transposable elements widespread in eukaryotes and related to DNA viruses. Gene. 2007 Apr 1;390(1-2):3-17. 

Sharma TP and Clark AF “Eye: Proteomics” eLS John Wiley & Sons, Ltd, 10.1002/9780470015902.a0006224.pub3, 2017 Nov. 

Wordinger RJ, Sharma T, Clark AF. The role of TGF-β2 and bone morphogenetic proteins in the trabecular meshwork and glaucoma. J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):154-62. 

Translaminar Autonomous System: A model to allow modulation of translaminar pressure in a donor human posterior eye cup. The intraocular and intracranial pressure can be altered independently of each other using this model system. U.S. Patent No.  US11678658B2 “DEVICES, SYSTEMS, AND METHODS FOR MODELING OCULAR TRANSLAMINAR PRESSURE GRADIENTS